The Design and Synthesis of Antimalarial Agents
The Design and Synthesis of Antimalarial Agents is a comprehensive yet accessible guide for those involved in the design, development and administration of antimalarial drugs. The book's aim is to support medicinal chemists in their search for improved and novel antimalarial drugs, providing practical guidance on current developments and highlighting promising leads. Beginning with a focus on the biological aspects of malaria, the book discusses the lifecycle of the parasite responsible for malaria, the problem of resistance, combinational therapy, genetic mapping of the parasite s genome, established drug targets, and potential drug targets for the future.
In addition, it covers the medicinal chemistry of antimalarial agents in detail, with a focus on the design of antimalarial drugs supported by a review of the drug categories that have reached the market, as well as those in the pipeline. Finally, the synthesis of different classes of antimalarial agents is reviewed, including a discussion on chemical and process development.
- Consolidates, for the first time, current developments in the discovery, design and synthesis of antimalarial drugs
- Presents content in a style that is both thorough and engaging, supporting and encouraging students and researchers from interdisciplinary backgrounds
- Highlights which drug targets are currently considered to be the most promising for future therapies and the classes of compounds being studied and perfected
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His academic career has included positions at Leeds and Strathclyde Universities as well as the Australian National University. He joined the University of the West of Scotland in 1990 and has written a number of scientific books, which have an international reputation. An associate lecturer for the Open University with a particular interest in developing novel teaching techniques, Dr. Patrick is also a Member of the Royal Society of Chemistry, and a Fellow of the Higher Education Academy.
An indispensable guide to current developments in medicinal chemistry for the creation of enhanced novel and innovative antimalarial drugs