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Antimalarial Agents

Design and Mechanism of Action

Antimalarial Agents - ISBN: 9780081012109
Prijs: € 200,00 (onder voorbehoud)
Beschikbaarheid: Nog niet verschenen.
Bindwijze: Boek, Paperback (12-06-2020)
Genre: Organische chemie
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Antimalarial Agents: Design and Mechanism of Action seeks to support medicinal chemists in their work towards antimalarial solution, providing practical guidance on current developments and highlighting promising leads for the future.

Malaria is a deadly disease which threatens half of the world s population. Advances over the last decade have seen vast improvements in the effectiveness of both preventative measures and treatments, but the rapid adaptability of the disease means that the ongoing search for improved and novel antimalarial drugs is essential.

Beginning with a focus on biological aspects of malaria, this book highlights the lifecycle of the parasite responsible for malaria, the problem of resistance, genetic mapping of the parasite s genome, established drug targets, and potential drug targets for the future. The book also includes detailed study of the medicinal chemistry of antimalarial agents and a focus on the design of antimalarial drugs.

Drawing on the knowledge of its expert authors and coupling historic research with current findings to provide a full picture of both past and current milestones, Antimalarial Agents: Design and Mechanism of Action is a comprehensive yet accessible guide for all those involved in the design, development and administration of antimalarial drugs, including academic researchers, medicinal chemists, malaria researchers and pharmaceutical scientists.

  • Consolidates current developments in the discovery and design of antimalarial drugs
  • Presents content in a style that is both thorough and engaging, providing a supportive and guiding reference to students and researchers from interdisciplinary backgrounds
  • Highlights drug targets currently considered to be the most promising for future therapies, and the classes of compounds that are currently being studied and perfected


Titel: Antimalarial Agents
Mediatype: Boek
Bindwijze: Paperback
Taal: Engels
Aantal pagina's: 622
Uitgever: Elsevier Science
Publicatiedatum: 2020-06-12
NUR: Organische chemie
Afmetingen: 229 x 152
ISBN/ISBN13: 9780081012109
Intern nummer: 40095097

Biografie (woord)

Dr. Patrick gained his BSc Honours at Glasgow University, winning the McKay-Smith Prize for Chemistry. He completed his PhD with Professor Kirby and Professor Robins studying the biosynthesis of gliotoxin and related fungal metabolites. Following this, he was employed in the pharmaceutical industry as a research chemist and radiochemist working on a variety of projects that included topic areas such as opioids, antibacterial agents and antidepressants.

His academic career has included positions at Leeds and Strathclyde Universities as well as the Australian National University. He joined the University of the West of Scotland in 1990 and has written a number of scientific books, which have an international reputation. An associate lecturer for the Open University with a particular interest in developing novel teaching techniques, Dr. Patrick is also a Member of the Royal Society of Chemistry, and a Fellow of the Higher Education Academy.

Extra informatie

An indispensable guide to current developments in medicinal chemistry for the creation of enhanced novel and innovative antimalarial drugs


1. Historical overview of malaria and its treatment 2. Knowing one s enemy: The Plasmodium parasite 3. The cinchona alkaloids and the aminoquinolines 4. Artemisinin and artemisinin-related agents 5. Agents acting on pyrimidine metabolism 6. Antimalarial agents acting on hemoglobin degradation 7. Plasmepsin inhibitors 8. Falcipain inhibitors 9. Agents acting on apicoplast pathways 10. Drugs targeting mitochondrial functions 11. Proteasome inhibitors 12. Transferase inhibitors 13. Kinase inhibitors 14. Miscellaneous agents of clinical interest 15. Inhibitors of purine and pyrimidine pathways 16. Miscellaneous targets


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