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Boek

Antimalarial Agents

Design and Mechanism of Action

Antimalarial Agents - ISBN: 9780081012109
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Bindwijze: Boek, Paperback (02-06-2020)
Genre: Organische chemie
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Beschrijving

Antimalarial Agents: Design and Mechanism of Action seeks to support medicinal chemists in their work toward antimalarial solutions, providing practical guidance on past and current developments and highlighting promising leads for the future.

Malaria is a deadly disease which threatens half of the world s population. Advances over several decades have seen vast improvements in the eff ectiveness of both preventative measures and treatments, but the rapid adaptability of the disease means that the ongoing search for improved and novel antimalarial drugs is essential.

Beginning with a historical overview of malaria and antimalarial research, this book goes on to describe the biological aspects of malaria, highlighting the lifecycle of the parasite responsible for malaria, the problem of resistance, genetic mapping of the parasite s genome, established drug targets, and potential drug targets for the future. This sets the scene for the following chapters which provide a detailed study of the medicinal chemistry of antimalarial agents, with a focus on the design of antimalarial drugs.

Drawing on the knowledge of its experienced authors, and coupling historic research with current fi ndings to provide a full picture of both past and current milestones, Antimalarial Agents: Design and Mechanism of Action is a comprehensive yet accessible guide for all those involved in the design, development, and administration of antimalarial drugs, including student academic researchers, medicinal chemists, malaria researchers, and pharmaceutical scientists.



  • Consolidates both past and current developments in the discovery and design of antimalarial drugs
  • Presents content in a style that is both thorough and engaging, providing a supportive and guiding reference to students and researchers from interdisciplinary backgrounds
  • Highlights drug targets currently considered to be the most promising for future therapies, and the classes of compounds that are currently being studied and perfected

Details

Titel: Antimalarial Agents
Mediatype: Boek
Bindwijze: Paperback
Taal: Engels
Aantal pagina's: 622
Uitgever: Elsevier Science
Publicatiedatum: 2020-06-02
NUR: Organische chemie
Afmetingen: 229 x 152
ISBN/ISBN13: 9780081012109
Intern nummer: 40095097

Biografie (woord)

Dr. Patrick gained his BSc Honours at Glasgow University, winning the McKay-Smith Prize for Chemistry. He completed his PhD with Professor Kirby and Professor Robins studying the biosynthesis of gliotoxin and related fungal metabolites. Following this, he was employed in the pharmaceutical industry as a research chemist and radiochemist working on a variety of projects that included topic areas such as opioids, antibacterial agents and antidepressants.

His academic career has included positions at Leeds and Strathclyde Universities as well as the Australian National University. He joined the University of the West of Scotland in 1990 and has written a number of scientific books, which have an international reputation. An associate lecturer for the Open University with a particular interest in developing novel teaching techniques, Dr. Patrick is also a Member of the Royal Society of Chemistry, and a Fellow of the Higher Education Academy.

Extra informatie

An indispensable guide to current developments in medicinal chemistry for the creation of enhanced antimalarial drugs

Inhoudsopgave

1. History of malaria and its treatment 2. Knowing one's enemy: the Plasmodium parasite 3. The cinchona alkaloids and the aminoquinolines 4. Artemisinin and artemisinin-related agents 5. Agents acting on pyrimidine metabolism 6. Antimalarial agents acting on hemoglobin degradation 7. Plasmepsins as targets for antimalarial agents 8. Falcipains as drug targets in antimalarial therapy 9. Drug targets in the apicoplast 10. Drugs targeting mitochondrial functions 11. The Plasmodium falciparum proteasome as a drug target 12. Transferases and their inhibition 13. Kinases and kinase inhibitors 14. Miscellaneous agents of clinical interest 15. Inhibitors of purine and pyrimidine pathways 16. Miscellaneous targets

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