Preface vii

Contributors ix

1 The Telomerase Complex: An Overview 1
Johanna Mancini and Chantal Autexier

2 Telomerase RNA: Structure, Function, and Molecular Mechanisms 23
Yehuda Tzfati and Julian J.–L. Chen

3 TERT Structure, Function, and Molecular Mechanisms 53
Emmanuel Skordalakes and Neal Lue

4 Telomerase Biogenesis: RNA Processing, Trafficking, and Protein Interactions 79
Tara Beattie and Pascal Chartrand

5 Transcriptional Regulation of Human Telomerase 105
Antonella Farsetti and Yu–Sheng Cong

6 Telomerase Regulation and Telomere–Length Homeostasis 135
Joachim Lingner and David Shore

7 Telomere Structure in Telomerase Regulation 157
Momchil D. Vodenicharov and Raymund J. Wellinger

8 Off–Telomere Functions of Telomerase 201
Kenkichi Masutomi and William C. Hahn

9 Murine Models of Dysfunctional Telomeres and Telomerase 213
Yie Liu and Lea Harrington

10 Cellular Senescence, Telomerase, and Cancer in Human Cells 243
Phillip G. Smiraldo, Jun Tang, Jerry W. Shay, and Woodring E. Wright

11 Telomerase, Retrotransposons, and Evolution 265
Irina R. Arkhipova

Index 301