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Sodium Channels, Pain, And Analgesia

Sodium Channels, Pain, And Analgesia - Coward, Kevin (EDT)/ Baker, Mark D. (EDT) - ISBN: 9783764370626
Prijs: € 212,10
Levertijd: 4 tot 6 werkdagen
Bindwijze: Boek, Gebonden
Genre: Medische handboeken (professioneel)
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Beschrijving

This Volume Provides Recent Insights Into The Control Of Expression, Functioning And Membrane Trafficking Of Nervous System Sodium Channels And Reviews Why Sodium Channel Sub-types Are Potentially Important Drug Targets In The Treatment Of Pain.

Details

Titel: Sodium Channels, Pain, And Analgesia
auteur: Coward, Kevin (EDT)/ Baker, Mark D. (EDT)
Mediatype: Boek
Bindwijze: Gebonden
Taal: Engels
Aantal pagina's: 202
Uitgever: Birkhauser Verlag Ag
Plaats van publicatie: CH
NUR: Medische handboeken (professioneel)
Collectie: Progress in Inflammation Research (PIR)
Afmetingen: 244 x 170
Gewicht: 556 gr
ISBN/ISBN13: 3764370629
ISBN/ISBN13: 9783764370626
Intern nummer: 3693927

Extra informatie

Sodium channels confer excitability on neurons in nociceptive pathways and exhibit neuronal tissue specific and injury regulated expression. This volume provides recent insights into the control of expression, functioning and membrane trafficking of nervous system sodium channels and reviews why sodium channel sub-types are potentially important drug targets in the treatment of pain. The roles of sodium channels in dental and visceral pain are also addressed. The emerging role of sodium channel Nav1.3 in neuropathic states is another important theme.Authors from the pharmaceutical industry discuss pharmacological approaches to the drug targeting of sodium channels, and in particular Nav1.8, exclusively expressed in nociceptive neurons. The final chapter highlights the functional diversity of sodium channels in part provided by post-transcriptional processing and the insights into sodium channel function that are being provided by tissue specific and inducible gene knock-out technology.

Inhoudsopgave

Voltage-gated sodium channels and pain associated with nerve injury and neuropathies.- Current approaches for the discovery of novel NaV channel inhibitors for the treatment of brain disorders.- Voltage-gated sodium channels and visceral pain.- The functional interaction of accessory proteins and voltage-gated sodium channels.- Sodium channels and nociceptive nerve endings.- Signalling cascades that modulate the activity of sodium channels in sensory neurons.- NaV1.8 as a drug target for pain.- Role of voltage-gated sodium channels in oral and craniofacial pain.- Sodium channel gating and drug blockade.- Future directions in sodium channel research.

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