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Serotonin

The Mediator that Spans Evolution

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Serotonin - ISBN: 9780128000502
Prijs: € 169,60 (onder voorbehoud)
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Bindwijze: Boek, Gebonden (01-11-2018)
Genre: Gezondheidswetenschappen
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Beschrijving

Serotonin: The Mediator that Spans Evolution provides a comprehensive review of the widespread roles for serotonin in respiratory, cardiovascular and thermoregulatory control, and growth and development in early life. This important resource highlights serotonin s role in normal (unstressed) conditions and in response to a variety of physiological stressors. It focuses on new animal models, comparing and contrasting data from mice and rats. It also compares and contrasts physiological effects of brain and blood serotonin systems. Included is new data that suggests the influence of serotonin is in part through the regulation of gene expression - this includes important proteins within the serotonin system itself, as well as proteins in interacting neurotransmitter systems. Finally, it discusses the role of serotonin system dysfunction in a variety of pathophysiological conditions, including sleep apnea, obesity and hypertension; and provides compelling evidence that this dysfunction is involved in Sudden Infant Death Syndrome (SIDS).



  • Includes the latest information on new animal models of serotonin system dysfunction
  • Explores the wide scope of serotonin s influence on multiple organ and physiological systems
  • Highlights the autonomous functioning of the brain and body serotonin systems
  • Provides compelling evidence of serotonin dysfunction in SIDS, a leading cause of death in infancy

Details

Titel: Serotonin
Mediatype: Boek
Bindwijze: Gebonden
Taal: Engels
Aantal pagina's: 480
Uitgever: Elsevier Science
Publicatiedatum: 2018-11-01
NUR: Gezondheidswetenschappen
Afmetingen: 276 x 216
ISBN/ISBN13: 9780128000502
Intern nummer: 42581899

Biografie (woord)

Paul M Pilowsky began his career as a graduate student investigating, inter alia, the role of brainstem and spinal cord pathways in the control of blood pressure with a focus on serotonin. His work has now been cited more than 5000 times and published in major Journals including the Journal of Neuroscience, the Journal of Comparative Neurology and the British Journal of Pharmacology. A hallmark of his work has been the adoption of, and combination of, novel approaches to address difficult questions. He pioneered the use of combining single cell electrophysiology in vivo with immunohistochemistry. His development of isotype selective monoclonal antibodies to phosphorylated tyrosine hydroxylase enabled the detection of tyrosine hydroxylase positive presympathetic neurons in the brainstem that had become excited.
He was responsible for the initial development of a new medical school at Macquarie University in Sydney. His service to Neuroscience was recognised by the award of the Australian Neuroscience Medal. He mentored 26 graduate students to on-time completion, and mentored 24 post-Doctoral Fellows, many of whom now have their own established careers.
In imagining this book, it was felt that a departure from the usual highly focussed text would be of interest. Hence, a multi-Author volume has been created that reveals the multiple facets of a neurotransmitter with very broad actions.

Extra informatie

Resource containing the wide scope of serotonin s influence on multiple organs and the physiological systems

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