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Platelets - ISBN: 9780128134566
Prijs: € 261,60
Levertijd: onbekend
Bindwijze: Boek, Gebonden
Genre: Gezondheidswetenschappen
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Platelets, Fourth Edition, integrates the entire field of platelet biology, pathophysiology, and clinical medicine with contributions from 142 world experts from 18 countries. This award-winning reference provides clear presentations by basic scientists on the cellular, molecular, and genetic mechanisms of platelets and the role of platelets in thrombosis, hemorrhage, inflammation, antimicrobial host defense, wound healing, angiogenesis and cancer. It also provides start-of-the-art presentations by hematologists, cardiologists, stroke physicians, blood bankers, pathologists and other clinicians on platelet function testing, disorders of platelet numbers and function, antiplatelet therapy and therapy to increase platelet numbers and/or function.

Since the publication of the Third Edition of Platelets, there has been a rapid expansion of knowledge in both basic biology of platelets and the clinical approach to platelet-related diseases. This Fourth Edition of Platelets draws all this information into a single, comprehensive and authoritative resource.

  • Comprehensive and definitive source of state-of-the-art knowledge about platelets
  • Integrates the entire field of platelet biology, pathophysiology, and clinical medicine
  • Written for clinicians, pathologists and scientists by 142 world-renowned experts from 18 countries
  • Completely revised and updated, with 11 new chapters on topics such as platelet glycobiology, the platelet transcriptome, platelet inhibitory receptors, platelet function testing in clinical research trials, therapeutic platelet-rich plasma in wound healing, and new antiplatelet drugs
  • Full color textbook with over 250 illustrations and 15,000 references


Titel: Platelets
Mediatype: Boek
Bindwijze: Gebonden
Taal: Engels
Druk: 4
Aantal pagina's: 1268
Uitgever: Elsevier Science Publishing Co Inc
Plaats van publicatie: 03
NUR: Gezondheidswetenschappen
Afmetingen: 227 x 286 x 55
Gewicht: 2664 gr
ISBN/ISBN13: 9780128134566
Intern nummer: 43272192

Extra informatie

The definitive source on platelets, covering the entire field of platelet biology, pathophysiology and clinical medicine


Accolades for Previous Editions:
Best Book in Medical Science Award --Association of American Publishers
Highly Commended Prize (Internal Medicine) --British Medical Association Medical Book Awards
"Belongs on the bookshelf of every clinician who assesses patients with platelet disorders" --The Lancet
"Landmark" --New England Journal of Medicine
"This is a fantastic resource for anyone who treats patients with platelet disorders or is engaged in platelet or megakaryocyte-based research" --British Journal of Haematology


PART I: Platelet Biology 1. The Evolution of Mammalian Platelets 2. Megakaryocyte Development and Platelet Formation 3. The Structure of Resting and Activated Platelets 4. Platelet Glycobiology and the Control of Platelet Function and Lifespan 5. Platelet Genomics 6. Platelet MicroRNAs 7. The Platelet Transcriptome in Health and Disease 8. The Platelet Proteome 9. Platelet Receptors 10. The Glycoprotein Ib-IX-V Complex 11. GPVI and CLEC-2 12. Integrin IIb3 13. Protease-Activated Receptors 14. The Platelet P2 Receptors 15. Platelet Inhibitory Receptors 16. Interactions Between Platelets, Leukocytes, and the Endothelium 17. Inhibition of Platelet Function by the Endothelium 18. Platelet Signal Transduction 19. Platelet Secretion 20. Hemostatic Thrombus Formation in Flowing Blood 21. Interactions Between Platelets and the Coagulation System 22. Platelet-Derived Extracellular Vesicles 23. Regulation of Fibrinolysis by Platelets 24. The Role of Platelets in Angiogenesis 25. Platelet Function in the Newborn

PART II: The Role of Platelets in Disease 26. The Role of Platelets in Atherothrombosis 27. The Role of Platelets in Diabetes Mellitus 28. The Role of Platelets in Inflammation 29. The Role of Platelets in Antimicrobial Host Defense 30. The Role of Platelets in Tumor Growth, Metastasis, and Immune Evasion 31. The Role of Platelets in Sickle Cell Disease

PART III: Clinical Tests of Platelet Function 32. Platelet Counting 33. Clinical Tests of Platelet Function 34. Platelet Aggregation 35. Flow Cytometry 36. Laboratory Monitoring of Antiplatelet Therapy 37. Platelet Function Testing in Clinical Research Trials

PART IV: Disorders of Platelet Number and/or Function 38. The Clinical Approach to Disorders of Platelet Number and Function 39. Immune Thrombocytopenia (ITP) 40. Drug-Induced Thrombocytopenia 41. Heparin-Induced Thrombocytopenia 42. Thrombotic Thrombocytopenic Purpura and Hemolytic-Uremic Syndromes 43. Thrombocytopenia in Pregnancy 44. Thrombocytopenia in the Newborn 45. Alloimmune Thrombocytopenia 46. Inherited Thrombocytopenias 47. Thrombocytosis and Essential Thrombocythemia 48. Inherited Disorders of Platelet Function 49. Acquired Disorders of Platelet Function

PART V: Antiplatelet Therapy 50. Aspirin 51. P2Y12 Antagonists 52. IIb3 (GPIIb-IIIa) Antagonists 53. PAR-1 Antagonists 54. Phosphodiesterase Inhibitors 55. Novel Antiplatelet Therapies 56. Antiplatelet Drugs in the Management of Coronary Artery Disease 57. Antiplatelet Drugs in the Management of Cerebral Ischemia 58. Antiplatelet Drugs in the Management of Thrombotic/Ischemic Events in Peripheral Artery Disease 59. Antiplatelet Drugs in the Management of Venous Thromboembolism, Cardioembolism, Ventricular Assist Devices, and Pregnancy Complications 60. Antiplatelet Drugs in the Management of Thrombotic/Ischemic Events in Children

PART VI: Therapy to Increase Platelet Numbers and/or Function 61. Thrombopoietin Receptor Agonists 62. Desmopressin (DDAVP) 63. Factor VIIa 64. Platelet Transfusion Medicine 65. Therapeutic Platelet-Rich Plasma in Wound Healing 66. Stem Cell-Derived Platelets 67. Gene Therapy for Platelet Disorders


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