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Dynemicin A, Uncialamycin and Analogues

Dynemicin A, Uncialamycin and Analogues - Weghe, Pierre Van De; Jean, Mickael; Best, Daniel - ISBN: 9781785481505
Prijs: € 95,75
Levertijd: 12 tot 15 werkdagen
Bindwijze: Boek, Gebonden (14-06-2016)
Genre: Farmacie, farmacotherapie
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Enediynes are natural products with highly active cytotoxicity and antibacterial activity, and thus have significant potential in the development of anti-cancer treatments. However, they are not readily available and can degrade rapidly during isolation; one solution is to produce them using total synthesis. Dynemicin A and uncialamycin are two such enediynes, with similar structures, for which total synthesis has been achieved. This book presents the isolation and preparation of these two compounds and their analogues through various synthesis strategies. Details of the structural elements essential to their anti-cancer activity are presented, with the objective of explaining and optimizing their biological activities and potential development as drugs.

  • Presents two natural nediynes with similar structures whose total syntheses have been accomplished
  • Explores structural analogs of preparation for purposes of optimizing the anti-cancer activity
  • Describes the total syntheses of dynemicin A, the uncialamycine, as well as analogs by emphasizing the synthesis strategies adopted
  • Features studies of the biological activities and data to bring out the structural elements of these essential compounds


Titel: Dynemicin A, Uncialamycin and Analogues
auteur: Weghe, Pierre Van De; Jean, Mickael; Best, Daniel
Mediatype: Boek
Bindwijze: Gebonden
Taal: Engels
Aantal pagina's: 144
Uitgever: Elsevier Science
Plaats van publicatie: 03
Publicatiedatum: 2016-06-14
NUR: Farmacie, farmacotherapie
Afmetingen: 229 x 152
ISBN/ISBN13: 9781785481505
Intern nummer: 33491271

Biografie (woord)

Pierre van de Weghe is Professor in organic chemistry at the University of Rennes 1 in France. His work focuses on the total synthesis of natural products and analogues, as well as research into new components in anti-cancer activity..

Extra informatie

This detailed resource describes the isolation of dynemicin and uncialamycin, provides a brief overview of their biological activities (and potential development as drugs), and presents the various synthetic routes to prepare these compounds and their analogues. Covers a complete field of organic chemistry at the interface with biological science.


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